San Francisco 49ers at Detroit Lions — Odds, Picks & Preview
Compare moneyline, spread, and total odds for San Francisco 49ers at Detroit Lions across 5 sportsbooks. The best price on each side is highlighted so you can shop the line in one place.
Odds last updated
Game info
- Kickoff
- Sun, Nov 15, 8:20 PM ET
- Venue
- Ford Field, Detroit, MI
- TV
- FOX
- Week
- Week 11 · 2026 season
Moneyline
| Sportsbook | San Francisco 49ers | Detroit Lions | Bet |
|---|---|---|---|
| DraftKings | +100 | -120 | DraftKings |
| FanDuel | +102 | -122 | FanDuel |
| BetMGM | +104 | -124 | BetMGM |
| Caesars | +106 | -126 | Caesars |
| BetRivers | +105 | -125 | BetRivers |
● highlights the best available price. Demo data — odds are illustrative.
Spread
Line -1.5| Sportsbook | San Francisco 49ers | Detroit Lions | Bet |
|---|---|---|---|
| DraftKings | +1.5 -110 | -1.5 -110 | DraftKings |
| FanDuel | +1.5 -108 | -1.5 -112 | FanDuel |
| BetMGM | +1.5 -112 | -1.5 -108 | BetMGM |
| Caesars | +1.5 -106 | -1.5 -114 | Caesars |
| BetRivers | +1.5 -114 | -1.5 -106 | BetRivers |
● highlights the best available price. Demo data — odds are illustrative.
Total
Line 51.5| Sportsbook | Over | Under | Bet |
|---|---|---|---|
| DraftKings | 51.5 -110 | 51.5 -110 | DraftKings |
| FanDuel | 51.5 -112 | 51.5 -108 | FanDuel |
| BetMGM | 51.5 -108 | 51.5 -112 | BetMGM |
| Caesars | 51.5 -115 | 51.5 -105 | Caesars |
| BetRivers | 51.5 -106 | 51.5 -114 | BetRivers |
● highlights the best available price. Demo data — odds are illustrative.
Market average vs. best book
Consensus odds aggregated across the sportsbook field. When a book pays more than the market average, it's beating the field on that side.
Moneyline
- San Francisco 49ers Beats marketAvg +103 Best +106 Caesars
- Detroit Lions Beats marketAvg -123 Best -120 DraftKings
Spread
- San Francisco 49ers +1.5 Beats marketAvg -110 Best -106 Caesars
- Detroit Lions -1.5 Beats marketAvg -110 Best -106 BetRivers
Total
- Over 51.5 Beats marketAvg -110 Best -106 BetRivers
- Under 51.5 Beats marketAvg -110 Best -105 Caesars
Demo data — consensus lines are illustrative.
Our analysts' pick for San Francisco 49ers at Detroit Lions
A full editorial preview and best bet for this game is on the way. The market currently has Detroit Lions favored at -1.5 with a total of 51.5 . Check the comparison tables above for the best available number on each side before you bet.
Bet at a sportsbook
Affiliate links are placeholders pending partnerships.
New to a book? Read our reviews: DraftKings · FanDuel · BetMGM · Caesars · BetRivers